More recently, she starred with a stellar ensemble in Emilio Estevez's Bobby, about the assassination of Robert F. Kennedy, which premiered at the 2006 AFI Film Festival. That same year, she starred in several independent films: Gray Matters, with Bridget Moynahan; the drama Broken, opposite Jeremy Sisto; the comedy The OH in Ohio, with Paul Rudd and Parker Posey; and Adrift in Manhattan, opposite Victor Rasuk for director Alfredo De Villa.
Throughout her career, Graham has worked with some of the industry's most respected actors and directors. Her performances include that of a doe-eyed girl in Swingers, with Jon Favreau and Vince Vaughn; an ambitious young actress in Frank Oz's Bowfinger, with Steve Martin and Eddie Murphy; and the tragic Mary Kelly in Albert and Allen Hughes' From Hell, opposite Johnny Depp, as well as roles in The Guru, with Marisa Tomei; Hope Springs, opposite Colin Firth; Committed, with Luke Wilson; Ed Burns' ensemble Sidewalks of New York; James Toback's Two Girls and a Guy, with Robert Downey Jr.; Lost in Space, with Gary Oldman and William Hurt; and Six Degrees of Separation, starring Will Smith.
Her upcoming film projects include Baby on Board, opposite Jerry O'Connell and John Corbett, and Boogie Woogie, alongside Stellan Skarsgard and Gillian Anderson, for director Duncan Ward.
Graham executive produced and starred in the feature film Cake, a romantic comedy also starring Sandra Oh and Cheryl Hines. In 2004-2005, she received rave reviews for her guest-starring stint on the critically acclaimed series Scrubs.
On stage, Graham made her theatrical debut off-Broadway in Playwrights Horizons' Recent Tragic Events.